Every time Rise flirts with the MC, take a sip.
Every time Rise is called Risette, take a sip.
Every time Naoto is referred to as the Detective Prince, take a sip.
Every time Yosuke denies that hes gay, take a sip.
Every time Yosuke says something that makes him seem gay, take two sips.
Every time the Midnight Channel comes on, take a sip.
Every time a character dies in-battle, take a sip.
Every time the girls terrible cooking is mentioned, take two sips.
Every time you see Mystery Food X, take three sips.
Every time Dojima drinks or smokes, take a sip.
Every time Nanako says big bro, take a sip.
Every time you go awwww at Nanako, take two sips.
Every time Naoto speaks in a high voice, take sip.
Every time someone blushes, take a sip.
Every time Igor messes up a fusion, drink half a bottle and swear at him.
Every time you make a Social Link, take a sip.
Every time you go up a rank in a Social Link, take one sip per rank.
Every time Saki is mentioned, take a sip.
Every time Namatame or Adachi calls Yamano Mayumi, take a sip.
When King Moron dies, drink the rest of the bottle from Igors mess-up and cheer.
Any time the gang are in swimsuits, take a sip.
Every time Kanji does something that points out his crush on Naoto, take a sip.
Every time you wonder how the heck Naoto doesnt realise that Kanjis in love with her, take two sips.
Every time Teddie sparkles, take a sip.
Every time someone denies their Shadow, take three sips and call them a moron.
Every time the boys get their butts kicked by the girls, drink a quarter of the bottle.
Every time Teddie acts perverted, take a sip.
Every time Kanjis sewing abilities are mentioned, take a sip.
Every time Shadow Yukiko calls Chie a prince, take a sip.
Every time Chie kicks someone, take a sip. Two if its Yosuke.
If you encounter the Reaper in a New Game+, take two sips.
When Naoto bails on the swimsuit competition, take three sips. Then take another three sips for Kanji, because hes too young to drink.
Every time Shadow Naoto switches personality, take a sip.
Whenever a reference to Persona 3 is made, take a sip.
Drink the whole way through the Kings Game because its just that funny.
When you find out who the copycat killer is, take a sip and shudder at his creepy eyes.
When you find out who the kidnapper is, drink half a bottle and swear at him for almost killing Nanako.
When you find out who the killer is, drink a whole bottle and stare disbelievingly at the screen.
When you find out who the puppeteer is, drink two bottles and swear at her.
When you crush Izanami-no-Okami with the Power of Friendship, drown yourself in your drink.
Every time a Shadow says something along the lines of "I'm you, you're me", take a drink.
Every time someone denies their Shadow, despite warnings from the group, take two sips and get your game on!
WARNING: ONLY ADD THE FOLLOWING TO THE ABOVE IF YOU'RE SUICIDAL
Every time you beat a boss, take a sip.
Every time you lose to a boss, take two sips and try again.
Every time you lose to Shadow Mitsuo, take five sips. Stupid @%$£ing baby!!
If Margaret absolutely pwns you in a NG+, take five sips.
If you beat Margaret in a NG+, take two sips and go pwn Nami-sama.
Choose one main character (team member or villain). If at any point you want to throttle said character, take a sip.
If you were stupid enough to choose Teddie on the above, then get your sorry self to the hospital ASAP.
Every time someone is drunk, take a sip.
If you find the Reaper in Yukiko's Castle, take three sips and mourn the MC.
Every time the characters are trying to figure out who the killer is, take a sip.
Every time Teddie mentions "yukata", take a sip. (credit Metal-AeroPathX)
Take 3 sips when Chie sings the Filet Mignon song. (credit Metal-AeroPathX)
Take a sip every time someone does that wrist flick hand gesture to emphasize their words. (credit Metal-AeroPathX)
Every time Teddie mentions "scoring", take a sip.
When Naoto wouldn't come out to the stage in a bathing suit for the beauty contest, chug the bottle and think "Damn, Kanji was so close." (credit Kingdomkey202)
Note: you may wish to add some of the above rules to the anime. If you do, may God have mercy on your soul...
Every time Aika Nakamura shows up, take a drink.
Every time a Persona awakens, take a sip.
Take one sip for every Shadow Rise in the striptease.
Every time Yu is perverted, take a sip.
When Yu takes out Shadow Teddie in ONE FREAKING HIT, down a bottle after staring at your screen in shock.
Every time "Sky's The Limit" or "Beauty of Destiny" play, take a sip and ROCK OUT!
When Yu's phone goes off with that song from Catherine, take two sips.
When Adachi shows up that one time with the all the cabbages, take three sips.
Every time Yu is looking paticularily "fine", drink the whole bottle (as if you needed beer goggles).
Every time King Moron, Hanako or Ms. Kashiwagi are on the screen, drink the whole bottle (you actually DO need the beer goggles this time).
Every time someone calls Yu "Narukami", take a sip.
Every time Kanji blushes in Naoto's presence, take a sip, or two if you ship them. (credit Kingdomkey202)
Drink half of another bottle if you laughted from Kanji having a nosebleed over Naoto. (credit Kingdomkey202)